Recombinant Human CCL4/MIP-1 beta Protein

重组人巨噬细胞炎性蛋白1β | 重组人 CCL4/MIP-1 beta 蛋白

ACT2 | ACT-2 | AT744.1 | C-C motif chemokine 4 | CCL4 | chemokine (C-C motif) ligand 4 | Exodus-3 | G-26 T-lymphocyte-secreted protein | G-26 | HC21 | LAG1 | LAG-1 | Lymphocyte activation gene 1 protein | Macrophage inflammatory protein 1-beta | MIP1 beta

rp143746-50μg

50μg

无动物源

≥96%(SDS-PAGE&HPLC)

＞96%(SDS-PAGE, HPLC)

Purity > 96 % by SDS-PAGE and HPLC analyses. Function Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.

Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 5.0-20 ng/ml.

重组表达

7.8 kDa

No tag

Full length protein

E. coli Accession #: P13236 | E. coli

<1.0 EU/μg

人(Human)

24-92 aa

APMGSDPPTA CCFSYTARKL PRNFVVDYYE TSSLCSQPAV VFQTKRSKQV CADPSESWVQ EYVYDLELN

Yes

Yes