Recombinant Human gp130 Protein

重组人糖蛋白130 | 重组人 CD130 (gp130) 蛋白

CD130 antigen | CD130 | CDw130 | DKFZp564F053 | gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form | gp130 | IL-6 receptor subunit beta | IL-6R subunit beta | IL-6RB | IL-6R-beta | IL6ST | interleukin 6 signal transducer (gp130, onco

rp143784-20μg

20μg

无动物源

≥95%(SDS-PAGE)

＞95%(SDS-PAGE)

Function Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events. Post-translational Phosphorylation of Ser-782 down-regulates cell surface expression. Heavily N-glycosylated.

Measured by its ability to inhibit IL-6-dependent proliferation of the 7TD1 mouse hybridoma cells in the presence of Recombinant Human IL-6 R alpha.The ED₅₀ for this effect is 0.65-6.5 ng/mL.

重组表达

95 kDa

C-hFc & His

HEK293 Accession #: P40189 | HEK293

<0.01 EU/μg

人(Human)

23-618 aa

ELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEI

Yes

Yes

Glu