Recombinant Human MCAM/CD146 Protein

重组人MCAM/CD146蛋白 | 重组人CD146分子蛋白 | 重组人MCAM/CD146蛋白 | 重组人CD146分子蛋白 | 重组人MCAM/CD146蛋白 | 重组人CD146分子蛋白

CD146 antigen | CD146 | cell surface glycoprotein MUC18 | Cell surface glycoprotein P1H12 | L-Gicerin | MCAM | melanoma adhesion molecule | melanoma cell adhesion moleculeS-endo 1 endothelial-associated antigen | Melanoma-associated antigen A32 | Melanoma

rp143805-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Function Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.

1. Measured by its binding ability in a functional ELISA. When Recombinant Human MCAM/CD146 is immobilized at 1 μg/mL, 100 μL/well, it binds Recombinant Human Galectin-3. The concentration of Recombinant Human Galectin-3 that produces 50% of the optimal binding response is 0.25‑1.25 μg/mL. 2. Immobilized Recombinant Human MCAM/CD146 Protein (rp143805) at 1 μg/mL can bind Imaprelimab (anti-CD146) (Ab175560) with the EC50 for this effect is 38.86 ng/mL.

重组表达

60.6 kDa

C-His

80 - 110 kDa, under reducing conditions; 80 - 110 kDa, under non-reducing conditions.

HEK293 Accession #: P43121-1 | HEK293

<0.1 EU/μg

人(Human)

24-559 aa

VPGEAEQPAPELVEVEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNVLVTPELLETGVECTASNDLGKNTSILFLELVNLTTLTPDSNTTTGLSTSTASPHTRANSTSTERKLPEPESRGHHHHHH

Yes

Yes