Recombinant Human DR6/TNFRSF21 Protein

重组人DR6/TNFRSF21蛋白 | 重组人肿瘤坏死因子受体超家族成员21蛋白

Death receptor 6 | BM-018 | CD358 antigen | CD358 | Death receptor 6 | DR6 | DR6TNFR-related death receptor 6 | MGC31965 | TNFRSF21 | tumor necrosis factor receptor superfamily member 21 | tumor necrosis factor receptor superfamily, member 21

rp145276-10μg

10μg

无动物源

≥95%(SDS-PAGE)

≥95% (SDS-PAGE)

Purity ≥95% SDS-PAGE. Endotoxin level Function May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).

Immobilized Human APP at 10 μg/mL (100 μL/well) can bind Human DR6 with a linear range of 0.002-1.8 μg/mL.

重组表达

65.5 kDa

C-hFc & His

95-100 kDa under reducing conditions

HEK293 Accession #: O75509 | HEK293

<0.1 EU/μg

人(Human)

1-350 aa

MGTSPSSSTALASCSRIARRATATMIAGSLLLLGFLSTTTAQPEQKASNLIGTYRHVDRATGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPVGTFTRHENGIEKCHDCSQPCPW

Yes

Yes