Recombinant Human Ephrin-B2 Protein

肝配蛋白B2(EFNB2)重组蛋白 | 重组人 Ephrin-B2 蛋白

EPH-related receptor tyrosine kinase ligand 5 | HTK ligand | HTK-L | LERK-5 | EFNB2 | ELF-2 | ephrin B2 | EphrinB2 | Ephrin-B2 | EPLG5 | HTKL | Htk-L | LERK5 | LERK-5 | NLERK-1 | Eph related receptor tyrosine kinase ligand 5 | Ligand of eph related kinase

rp145642-10μg

10μg

无动物源

≥95%(SDS-PAGE)

≥95% (SDS-PAGE)

Purity ≥95% (SDS-PAGE) Endotoxin level ＜0.1 EU/μg Function Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. (Microbial infection) Acts as a receptor for Hendra virus and Nipah virus.

Immobilized Recombinant Human Ephrin-B2 Protein (rp145642) at 1.0 μg/mL can bind Human EPHB4 with the ED50 for this effect is 504.8 ng/mL.

重组表达

23 kDa

C-His

30 - 40 kDa, under reducing conditions; 30 - 40 kDa, under non-reducing conditions.

HEK293 Accession #: P52799 | HEK293

<0.1 EU/μg

人(Human)

28-229 aa

IVLEPIYWNSSNSKFLPGQGLVLYPQIGDKLDIICPKVDSKTVGQYEYYKVYMVDKDQADRCTIKKENTPLLNCAKPDQDIKFTIKFQEFSPNLWGLEFQKNKDYYIISTSNGSLEGLDNQEGGVCQTRAMKILMKVGQDASSAGSTRNKDPTRRPELEAGTNGRSSTTSPFVKPNPGSSTDGNSAGHSGNNILGSEVALFAHHHHHH

Yes

Yes