Recombinant Human Frizzled-10 Protein

卷曲同源物10(FZD10)重组蛋白

Fz-10 | FzE7 | hFz10 | CD350 antigen | CD350 | frizzled (Drosophila) homolog 10 | frizzled homolog 10 (Drosophila) | Frizzled10 | Frizzled-10 | Fz10 | FZ-10 | FZD10 | FzE7 | hFz10

rp146214-10μg

10μg

无动物源

≥90%(SDS-PAGE)

Function Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Measured by its ability to bind biotinylated recombinant mouse Wnt-3a in a functional ELISA with an estimated Kd <5 nM.

重组表达

16.9 kDa

C-His

20-25 kDa, under reducing conditions

HEK293 Accession #: Q6NSL8 | HEK293

<0.1 EU/μg

人(Human)

21-161 aa

ISSMDMERPGDGKCQPIEIPMCKDIGYNMTRMPNLMGHENQREAVIQLHEFAPLVEYGCHGHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKNDPNYLCMEAPNNGSDEPTRGHHHHHH

Yes

Yes