Recombinant Human GDF6 Protein

重组人GDF6蛋白 | 重组人 GDF6 蛋白

Bmp 13 | BMP-13 | Bmp13 | Bone morphogenetic protein 13 | Cartilage Derived Morphogenetic Protein 2 | Cdmp 2 | CDMP2 | Gdf 6 | GDF-6 | GDF16 | Gdf6 | GDF6_HUMAN | Growth differentiation factor 6 | Growth/differentiation factor 16 | Growth/differentiation

rp146383-50μg

50μg

无动物源

≥95%(SDS-PAGE&HPLC)

＞95%(SDS-PAGE and HPLC)

Purity > 95% by SDS-PAGE and HPLC analyses. Function Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map (PubMed:23307924). Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal strucutres. Seems to positively regulates differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG (PubMed:26643732). Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38.

Fully biologically active when compared to standard. The ED₅₀ as determined by inducing alkaline phosphatase production of murine ATDC5 cells is less than 2.0 μg/ml, corresponding to a specific activity of > 500 IU/mg.

重组表达

27.1 kDa

No tag

27.1 kDa

Full length protein

E. coli Accession #: Q6KF10 | E. coli

<0.1 EU/μg

人(Human)

336-455aa

TAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGCR

Yes

Yes