Recombinant Human Serpin D1/Heparin Cofactor II Protein

重组人Serpin D1/Heparin Cofactor II蛋白 | 重组人肝素辅因子Ⅱ蛋白

HC-II | Heparin cofactor II | HLS2 | Protease inhibitor leuserpin-2 | Serpin D1 | HC2LS2 | HC2 | HCF2 | clade D (heparin cofactor), member 1 | HC-II | Heparin Cofactor II | HLS2 | HCII | leuserpin 2 | LS2 | Protease inhibitor leuserpin-2 | Serpin D1 | ser

rp146809-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Function Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.

Measured by its ability to inhibit Recombinant Human Coagulation Factor II/Thrombin cleavage of a fluorogenic peptide substrate Boc-VPR-AMC. The IC50 value is <1.5 nM, as measured under the described conditions.

重组表达

56 kDa

C-10His

62 kDa under reducing conditions.

HEK293 Accession #: P05546 | HEK293

<0.1 EU/μg

人(Human)

20-499 aa

GSKGPLDQLEKGGETAQSADPQWEQLNNKNLSMPLLPADFHKENTVTNDWIPEGEEDDDYLDLEKIFSEDDDYIDIVDSLSVSPTDSDVSAGNILQLFHGKSRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCLLFMGRVANPSRSHHHHHHHHHH

Yes

Yes