Recombinant Human IL-1 alpha/IL-1F1 Protein

重组人白细胞介素-1α蛋白 | 重组人IL-1 alpha蛋白(Active) | 重组人白细胞介素-1α蛋白 | 重组人IL-1 alpha蛋白(Active)

BAF | Hematopoietin-1 | IL1 alpha | IL-1 alpha | IL1 | IL1A | IL-1A | IL1-ALPHA | IL1F1 | IL-1F1 | IL1F1hematopoietin-1 | interleukin 1, alpha | interleukin-1 alpha | LAF | LEM | preinterleukin 1 alpha | pro-interleukin-1-alpha | FAF | Hematopoietin 1 | I

rp147340-10μg

10μg

无动物源

≥95%(SDS-PAGE)

≥95% (SDS-PAGE)

Purity ≥95% (SDS-PAGE) Endotoxin level ＜0.1 EU/μg Function Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. IL-1α is a non-secreted, proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes, and other epithelial cells. It possesses metabolic, physiological, hematopoietic activities, and plays one of the central roles in the regulation of the immune responses. Both IL-1α and IL-1β bind to the same receptor and have similar, if not identical, biological properties. These cytokines have a broad range of activities including the stimulation of thymocyte proliferation by inducing IL-2 release, B cell maturation and proliferation, mitogenic FGF-like activity and the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant Human IL-1α is an 18.0kDa protein containing 159 amino acid residues.

Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. The ED50 for this effect is 1‑10 ng/mL.

重组表达

18 kDa

C-His

20 - 25 kDa, under reducing conditions; 20 - 25 kDa, under non-reducing conditions.

HEK293 Accession #: P01583 | HEK293

<0.1 EU/μg

人(Human)

113-271 aa

SAPFSFLSNVKYNFMRIIKYEFILNDALNQSIIRANDQYLTAAALHNLDEAVKFDMGAYKSSKDDAKITVILRISKTQLYVTAQDEDQPVLLKEMPEIPKTITGSETNLLFFWETHGTKNYFTSVAHPNLFIATKQDYWVCLAGGPPSITDFQILENQAHHHHHH

Yes