Recombinant Human IL-28 R alpha/IFN-lambda R1 Protein

干扰素λ受体1重组蛋白 | 干扰素λ受体1重组蛋白

CRF2-12 | Cytokine receptor class-II member 12 | Cytokine receptor family 2 member 12 | IFN-lambda receptor 1 | IFN-lambda-R1 | IL-28 receptor subunit alpha | IL-28RA | IL-28R-alpha | Interleukin-28 receptor subunit alpha | LICR2 | Likely interleukin or c

rp147537-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Relevance IL-28RA is a class II cytokine receptor that interacts with IL10RB to bind IL28A, IL28B, and IL29, which are related to type I interferons. These ligands play a critical role in response to microbial challenge and activate the JAK/STAT signaling system. It heterodimers with IL10RB. There are 4 isoforms as result of alternative splicing. It is widely expressed. IL-28RA belongs to the type II cytokine receptor family, and contains 1 fibronectin type III domain.

Measured by its binding ability in a functional ELISA. In a 100 μL reaction mixture containing rhIL-28 R alpha /Fc Chimera at 1 μg/mL and rhIL-28A dilutions at 1-1000 ng/mL, the concentration of rhIL-28A that produces 50% of the optimal binding response is found to be approximately 40-200 ng/mL.

重组表达

51.5 kDa

C-hFc & His

70 kDa, under reducing conditions; 140 & 280 & 420 kDa, under non-reducing conditions.

HEK293 Accession #: Q8IU57 | HEK293

<0.1 EU/μg

人(Human)

21-228 aa

RPRLAPPQNVTLLSQNFSVYLTWLPGLGNPQDVTYFVAYQSSPTRRRWREVEECAGTKELLCSMMCLKKQDLYNKFKGRVRTVSPSSKSPWVESEYLDYLFEVEPAPPVLVLTQTEEILSANATYQLPPCMPPLDLKYEVAFWKEGAGNKTLFPVTPHGQPVQITLQPAASEHHCLSARTIYTFSVPKYSKFSKPTCFLLEVPEANWAENLYFQGMDPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH

Yes

Yes