Recombinant Human Kallikrein 6 Protein

重组人Kallikrein 6蛋白 | 重组人激肽释放酶6蛋白 | 重组人Kallikrein 6蛋白 | 重组人激肽释放酶6蛋白 | 重组人Kallikrein 6蛋白 | 重组人激肽释放酶6蛋白

EC 3.4.21.- | Neurosin | Protease M | Serine protease 18 | Serine protease 9 | SP59 | Zyme | Bssp | EC 3.4.21 | EC 3.4.21.- | hK6 | kallikrein 6 (neurosin, zyme) | Kallikrein 6 | kallikrein-6 | kallikrein-related peptidase 6 | KLK6 | Klk7 | Neurosin | Pro

rp147935-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Function Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.

Measured by its ability to cleave the fluorogenic peptide substrate Boc-QAR-AMC. The specific activity is >1300 pmol/min/µg, as measured under the described conditions.

26 kDa

C-10His

10 & 25 kDa, under reducing conditions; 25 - 30 kDa, under non-reducing conditions.

HEK293 Accession #: Q92876-1 | HEK293

<0.1 EU/μg

人(Human)

17-244 aa

EEQNKLVHGGPCDKTSHPYQAALYTSGHLLCGGVLIHPLWVLTAAHCKKPNLQVFLGKHNLRQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAKLSELIQPLPLERDCSANTTSCHILGWGKTADGDFPDTIQCAYIHLVSREECEHAYPGQITQNMLCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGVYTNVCRYTNWIQKTIQAKHHHHHHHHHH

Yes

Yes