Recombinant Human CCL8/MCP-2 Protein

重组人 CCL8/MCP-2 蛋白 | 重组人 CCL8/MCP-2 蛋白

C-C motif chemokine 8 | CCL8 | Chemokine (C-C motif) ligand 8 | HC14 | MCP2 | MCP-2 | Member 8 (monocyte chemotactic protein 2) | Monocyte chemoattractant protein 2 | SCYA10 | Small-inducible cytokine A8 | HC14 | MCP-2 | Monocyte chemoattractant protein 2

rp148607-50μg

50μg

无动物源

≥96%(SDS-PAGE&HPLC)

＞96%( SDS-PAGE and HPLC)

Purity Human CCL8, also known as monocyte chemotactic protein 2 (MCP-2), is belonging to the CC chemokine family. It is encoded by the gene CCL8. MCP-2 has two homogeneous MCP-1 (CCL2) and MCP-3 (CCL7). These three MCPs were found by IL-1-beta triggered human MG-63 osteosarcoma cells. CCL8 shares 62 % amino acid sequence identity with MCP-1, and shares 58 % amino acid sequence identity with MCP-2. CCL8 has chemotactic function for monocytes, eosinophils and neutrophils. In addition, it can also chemoattract activated NK cells. Purity >96% by SDS-PAGE and HPLC analyses. Additional sequence information Full-length mature C-C motif chemokine 8 chain lacking the signal peptide. Function Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8. Post-translational N-terminal processed form MCP-2(6-76) is produced by proteolytic cleavage after secretion from peripheral blood monocytes. MCP-2 and MCP-3 are two monocyte chemotactic proteins produced by human MG-63 osteosarcoma cells. Both MCP-2 and MCP-3 are members of the C-C family of chemokines and share 62% and 71% amino acid sequence identity, respectively, with MCP-1. MCP-3 also shares 58% amino acid identity with MCP-2. Similarly to other C-C chemokines, all three MCP proteins are monocyte chemoattractants. In addition, the three MCPs can chemoattract activated NK cells as well as CD4+ and CD8+ T lymphocytes. All three cytokines have also been shown to attract eosinophils and induce histamine secretion from basophils.

Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 10-100 ng/ml.

重组表达

8.9 kDa

No tag

8.9 kDa

E. coli Accession #: P80075 | E. coli

<1.0 EU/μg

人(Human)

24-99 aa

QPDSVSIPIT CCFNVINRKI PIQRLESYTR ITNIQCPKEA VIFKTKRGKE VCADPKERWV RDSMKHLDQI FQNLKP

Yes

Yes