Recombinant Human Meprin beta Subunit/MEP1B Protein

重组人Meprin beta Subunit/MEP1B蛋白 | 重组人安眠蛋白1β蛋白 | 重组人Meprin beta Subunit/MEP1B蛋白 | 重组人安眠蛋白1β蛋白

EC 3.4.24.63 | Endopeptidase-2 | Meprin B | N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta | PABA peptide hydrolase | PPH beta | EC 3.4.24.63 | endopeptidase-2 | MEP1B | meprin A subunit beta | meprin A, beta | Meprin B | Meprin beta Subu

rp148698-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Function Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components. Cleaves also the amyloid precursor protein/APP, thereby releasing neurotoxic amyloid beta peptides.

Measured by its ability to cleave a fluorogenic peptide substrate, Mca-SEVNLDAEFRK(Dpn)RR-NH2. The specific activity is >350 pmol/min/µg, as measured under the described conditions.

重组表达

66 kDa

C-10His

75 - 95 kDa, under reducing conditions; 75 - 95 & 180 - 220 kDa, under non-reducing conditions.

HEK293 Accession #: Q16820 | HEK293

<0.1 EU/μg

人(Human)

21-593 aa & 23-593 aa

LATPENFDVDGGMDQDIFDINEGLGLDLFEGDIRLDRAQIRNSIIGEKYRWPHTIPYVLEDSLEMNAKGVILNAFERYRLKTCIDFKPWAGETNYISVFKGSGCWSSVGNRRVGKQELSIGANCDRIATVQHEFLHALGFWHEQSRSDRDDYVRIMWDRILSGREHNFNTYSDDISDSLNVPYDYTSVMHYSKTAFQNGTEPTIVTRISDFEDVIGQRMDFSDSDLLKLNQLYNCSSSLSFMDSCSFELENVCGMIQSSGDNADWQRVSQVPRGPESDHSNMGQCQGSGFFMHFDSSSVNVGATAVLESRTLYPKRGFQCLQFYLYNSGSESDQLNIYIREYSADNVDGNLTLVEEIKEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGASLGGLSIDDINLSETRCPHHIWHIRNFTQFIGSPNGTLYSPPFYSSKGYAFQIYLNLAHVTNAGIYFHLISGANDDQLQWPCPWQQATMTLLDQNPDIRQRMSNQRSITTDPFMTTDNGNYFWDRPSKVGTVALFSNGTQFRRGGGYGTSAFITHERLKSRDFIKGDDVYILLTVEDISHLNSHHHHHHHHHH

Yes

Yes