Recombinant Human MUC-1 Protein

粘蛋白1(MUC1)重组蛋白 | 重组人类 MUC-1 蛋白

ADMCKD | ADMCKD1 | Breast carcinoma associated antigen DF3 | Breast carcinoma-associated antigen DF3 | CA 15-3 | CA15 3 | CA15 3 antigen | CA15-3 | CA15.3 | Cancer antigen 15-3 | Carcinoma associated mucin | Carcinoma-associated mucin | CD 227 | CD227 | D

rp148996-50μg

50μg

无动物源

≥95%(SDS-PAGE)

≥95% (SDS-PAGE)

Purity ≥95% (SDS-PAGE) Endotoxin level ＜0.1 EU/μg Function The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.

Measured by its ability to increase beta-catenin levels in the cytoplasm and nucleus of HCT116 human colon adenocarcinoma cells. 0.01-1 ng/mL of Recombinant Human MUC-1 can effectively increase beta-catenin levels.

重组表达

45 kDa

C-hFc & His

60-75 kDa, under reducing conditions

HEK293 Accession #: P15941-11 | HEK293

<0.1 EU/μg

人(Human)

1-167 aa

MTPGTQSPFFLLLLLTVLTATTAPKPATVVTGSGHASSTPGGEKETSATQRSSVPSSTEKNAFNSSLEDPSTDYYQELQRDISEMFLQIYKQGGFLGLSNIKFRPGSVVVQLTLAFREGTINVHDVETQFNQYKTEAASRYNLTISDVSVSDVPFPFSAQSGAGVPGENLYFQGMDPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH

Yes

Yes