Recombinant Human Nectin-3 Protein

重组人Nectin-3蛋白 | 重组人连接蛋白3蛋白

CDw113 | Nectin cell adhesion molecule 3 | Poliovirus receptor-related protein 3 | Poliovirus Receptor Related 3 | CD113 antigen | CD113 | CDw113 | FLJ90624 | DKFZp566B0846 | nectin 3 | Nectin3 | Nectin-3 | poliovirus receptor-related 3 | poliovirus recep

rp149160-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Function Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.

Measured by its binding ability in a functional ELISA. Immobilized rhNectin-3/his at 1 µg/mL can bind rhNectin-1/his with an apparent KD <120 nM.

重组表达

38 kDa

C-His

60 - 75 kDa, under reducing conditions; 55 - 70 kDa, under non-reducing conditions.

HEK293 Accession #: Q9NQS3-1 | HEK293

<0.1 EU/μg

人(Human)

56-400 aa & 58-400 aa

LAGPIIVEPHVTAVWGKNVSLKCLIEVNETITQISWEKIHGKSSQTVAVHHPQYGFSVQGEYQGRVLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDSLIDGGNETVAAICIAATGKPVAHIDWEGDLGEMESTTTSFPNETATIISQYKLFPTRFARGRRITCVVKHPALEKDIRYSFILDIQYAPEVSVTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNYSGVYICKVTNSLGQRSDQKVIYISDPPTTTTLQPTIQWHPSTADIEDLATEPKKLPFPLSTLATIKDDHHHHHH

Yes

Yes