Recombinant Human Osteoprotegerin Protein

重组人骨保护素蛋白 | 重组人TR11B蛋白 | 重组人骨保护蛋白

OCIF | OCIFMGC29565 | OPG | OPGtumor necrosis factor receptor superfamily member 11B | Osteoclastogenesis inhibitory factor | Osteoprotegerin | TNFRSF11B | TR1 | tumor necrosis factor receptor superfamily, member 11b | PDB5

rp149600-50μg

50μg

无动物源

≥95%(SDS-PAGE)

＞95%(SDS-PAGE, HPLC)

Purity > 95 % by SDS-PAGE and HPLC analyses. Function Osteoprotegerin (OPG), also named osteoclastogenesis inhibitory factor (OCIF), and tumor necrosis factor receptor superfamily member 11B (TNFRSF11B), is a TNFRSF11B-encoded protein in humans. Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.OPG has been applied to decrease bone resorption in women with postmenopausal osteoporosis and in patients with lytic bone metastases.

Fully biologically active when compared to standard. The ED50 as determined by neutralizing the stimulation of U937 cells is less than 10 ng/ml in the presence of 10 ng/mL soluble rHuRANKL (sRANKL).

重组表达

19.7 kDa

No tag

Protein fragment

E. coli Accession #: O00300 | E. coli

<1.0 EU/μg

人(Human)

22-194 aa

ETFPPKYLHY DEETSHQLLC DKCPPGTYLK QHCTAKWKTV CAPCPDHYYT DSWHTSDECL YCSPVCKELQ YVKQECNRTH NRVCECKEGR YLEIEFCLKH RSCPPGFGVV QAGTPERNTV CKRCPDGFFS NETSSKAPCR KHTNCSVFGL LLTQKGNATH DNICSGNSES TQK

Yes

Yes