Recombinant Human RANTES Protein

重组人RANTES蛋白 | 重组人类RANTES蛋白

CCL5 | chemokine (C-C motif) ligand 5 | D17S136Enormally T-expressed, and presumably secreted | EoCP | Eosinophil chemotactic cytokine | RANTES | SISd | SIS-delta | small inducible cytokine A5 (RANTES) | small inducible cytokine subfamily A (Cys-Cys), mem

rp150860-50μg

50μg

无动物源

≥98%(SDS-PAGE&HPLC)

＞98%(SDS-PAGE, HPLC)

Purity >98% by SDS-PAGE and HPLC analyses. Function Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.

Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 1.0-10 ng/ml.

重组表达

7.8 kDa

No tag

7.8 kDa

Full length protein

E. coli Accession #: P13501 | E. coli

<1.0 EU/μg

人(Human)

24-91 aa

SPYSSDTTPCCFAYIARPLPRAHIKEYFYTSGKCSNPAVVFVTRKNRQVCANPEKKWVREYINSLEMS

Yes

Yes