Recombinant Human TNF-alpha Protein

重组人tnfα蛋白 | 重组人肿瘤坏死因子α蛋白（TNF-alpha）TNF α

APC1 protein | Cachectin | Cachetin | DIF | TNF | TNF, monocyte-derived | TNFA | TNF-A | TNFalpha | TNF-alpha | TNF-alphacachectin | TNFATNF, macrophage-derived | TNFG1F | TNFSF1A | TNFSF2 | TNFSF2TNF superfamily, member 2 | tumor necrosis factor (TNF sup

rp152506-50μg

50μg

无动物源

≥95%(SDS-PAGE)

≥95% (SDS-PAGE)

Tumor necrosis factor-α (TNFα) is a kind of cytokine mainly produced by macrophages and monocytes, which can participate in the immune response and inflammatory response of the body. The increase of TNFα value is closely related to sepsis, malignant tumor, heart failure and chronic inflammatory diseases, which can be used as an evaluation index of disease condition, treatment effect and prognosis. At the same time, TNFα is also a key target of autoimmune diseases. Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia. Under certain conditions it can stimulate cell proliferation and induce cell differentiation.

Measured in a cytotoxicity assay using L‑929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D (Catalog # A113142). The ED₅₀ for this effect is typically <0.05 ng/mL.

重组表达

17.4 kD

No tag

Full length protein

E. coli Accession #: P01375 | E. coli

<0.1 EU/μg

人(Human)

77-233 aa

VRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVV PSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSP CQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQV YFGIIAL

Yes

Val