Recombinant Mouse gp130 Protein

重组小鼠gp130蛋白 | 重组小鼠糖蛋白130蛋白

Glycoprotein 130 | CD130 antigen | CD130 | CDw130 | DKFZp564F053 | gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form | gp130 | IL-6 receptor subunit beta | IL-6R subunit beta | IL-6RB | IL-6R-beta | IL6ST | interleukin 6 signal tran

rp153698-10μg

10μg

无动物源

≥90%(SDS-PAGE)

Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.

Measured by its ability to inhibit IL-6-dependent proliferation of the 7TD1 mouse hybridoma cells in the presence of Recombinant Human IL-6 R alpha. The ED50 for this effect is 1.8 ng/mL.

重组表达

67.5 kDa

C-His

80 - 100 kDa, under reducing conditions; 80 - 100 kDa, under non-reducing conditions.

HEK293 Accession #: Q6PDI9 | HEK293

<0.1 EU/μg

小鼠(Mouse)

23-617 aa

QLLEPCGYIYPEFPVVQRGSNFTAICVLKEACLQHYYVNASYIVWKTNHAAVPREQVTVINRTTSSVTFTDVVLPSVQLTCNILSFGQIEQNVYGVTMLSGFPPDKPTNLTCIVNEGKNMLCQWDPGRETYLETNYTLKSEWATEKFPDCQSKHGTSCMVSYMPTYYVNIEVWVEAENALGKVSSESINFDPVDKVKPTPPYNLSVTNSEELSSILKLSWVSSGLGGLLDLKSDIQYRTKDASTWIQVPLEDTMSPRTSFTVQDLKPFTEYVFRIRSIKDSGKGYWSDWSEEASGTTYEDRPSRPPSFWYKTNPSHGQEYRSVRLIWKALPLSEANGKILDYEVILTQSKSVSQTYTVTGTELTVNLTNDRYVASLAARNKVGKSAAAVLTIPSPHVTAAYSVVNLKAFPKDNLLWVEWTPPPKPVSKYILEWCVLSENAPCVEDWQQEDATVNRTHLRGRLLESKCYQITVTPVFATGPGGSESLKAYLKQAAPARGPTVRTKKVGKNEAVLAWDQIPVDDQNGFIRNYSISYRTSVGKEMVVHVDSSHTEYTLSSLSSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEHHHHHH

Yes

Yes