Recombinant Mouse B7-1/CD80 Protein

重组小鼠B7-1/CD80蛋白

Activation B7-1 antigen | B7 | B71 | B7-1 | BB1 | CD28LG1 | CD28LG | B7-1 antigen | CD80 antigen | CD80 molecule | CD80 | costimulatory factor CD80 | costimulatory molecule variant IgV-CD80 | CTLA-4 counter-receptor B7.1 | T-lymphocyte activation antigen

rp153775-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation. Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells together with the CD28 receptor which is constitutively expressed on the cell surface of T-cells. In turn, activates different signaling pathways such as NF-kappa-B or MAPK leading to the production of different cytokines. In addition, CD28/CD80 costimulatory signal stimulates glucose metabolism and ATP synthesis of T-cells by activating the PI3K/Akt signaling pathway. Acts also as a regulator of PDL1/PDCD1 interactions to limit excess engagement of PDL1 and its inhibitory role in immune responses. Expressed on B-cells, plays a critical role in regulating interactions between B-cells and T-cells in both early and late germinal center responses, which are crucial for the generation of effective humoral immune responses.

Immobilized Recombinant Mouse CD80 at 500ng/mL (100 μL/well) can bind Recombinant Human CTLA-4 with a linear range of 10-50 ng/mL.

重组表达

25 kDa

C-His

39-54 kDa, under reducing conditions.

HEK293 Accession #: Q00609 | HEK293

<0.1 EU/μg

小鼠(Mouse)

37-245 aa

DVDEQLSKSVKDKVLLPCRYNSPHEDESEDRIYWQKHDKVVLSVIAGKLKVWPEYKNRTLYDNTTYSLIILGLVLSDRGTYSCVVQKKERGTYEVKHLALVKLSIKADFSTPNITESGNPSADTKRITCFASGGFPKPRFSWLENGRELPGINTTISQDPESELYTISSQLDFNTTRNHTIKCLIKYGDAHVSEDFTWEKPPEDPPDSKHHHHHH

Yes

Yes