Recombinant Mouse Fas/TNFRSF6/CD95 Protein

凋亡相关因子(FAS)重组蛋白

Apo-1 antigen | Apo-1 | apoptosis antigen 1 | Apoptosis-mediating surface antigen FAS | APT1 | APT1FASTM | CD95 antigen | CD95 | CD95ALPS1A | Fas (TNF receptor superfamily, member 6) | Fas AMA | Fas antigen | Fas | FAS1 | FASLG receptor | TNFRSF6 | TNFRSF

rp153948-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Function Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).

Measured by its ability to inhibit Fas Ligand-induced apoptosis of Jurkat human acute T cell leukemia cells. The ED50 for this effect is 0.03‑0.1 µg/mL in the presence of 20 ng/mL recombinant human Fas-ligand.

重组表达

46 kDa

C-hFc & His

55 kDa, under reducing conditions

HEK293 Accession #: P25446 | HEK293

<0.1 EU/μg

小鼠(Mouse)

14-169 aa

GSQLRVHTQGTNSISESLKLRRRVRETDKNCSEGLYQGGPFCCQPCQPGKKKVEDCKMNGGTPTCAPCTEGKEYMDKNHYADKCRRCTLCDEEHGLEVETNCTLTQNTKCKCKPDFYCDSPGCEHCVRCASCEHGTLEPCTATSNTNCRKQSPRNRENLYFQGMDPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH

Yes

Yes