Recombinant Mouse IL-6 Protein

重组小鼠 IL-6 蛋白

B-cell differentiation factor | B-cell stimulatory factor 2 | BSF2 | BSF-2 | CDF | CTL differentiation factor | HSF | hybridoma growth factor | IFNB2 | IFN-beta-2 | IL6 | IL-6 | Interferon beta-2 | interleukin 6 (interferon, beta 2) | interleukin BSF-2 |

rp154236-50μg

50μg

无动物源

≥96%(SDS-PAGE&HPLC)

＞96%(SDS-PAGE,HPLC)

Interleukin-6 (IL-6) encoded by the IL-6 gene, acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response. IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. It stimulates B cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant Murine IL-6 is a 21.7kDa globular protein containing 188 amino acid residues. Purity ＞96%(SDS-PAGE,HPLC) Function Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.

Measured in a cell proliferation assay using M-NFS-60 mouse B cell. The ED₅₀ for this effect is less than 0.4 ng/mL.

重组表达

21.7 kDa

No tag

Full length protein

E. coli Accession #: P08505 | E. coli

<0.1 EU/μg

小鼠(Mouse)

25-211 aa

MFPTSQVRRGDFTEDTTPNRPVYTTSQVGGLITHVLWEIVEMRKELCNG NSDCMNNDDALAENNLKLPEIQRNDGCYQTGYNQEICLLKISSGLLEYH SYLEYMKNNLKDNKKDKARVLQRDTETLIHIFNQEVKDLHKIVLPTPIS NALLTDKLESQKEWLRTKTIQFILKSLEEFLKVTLRSTRQT

Yes

Yes

Met