Recombinant Mouse TIMP-1 Protein

重组小鼠TIMP-1蛋白 | 重组小鼠组织金属蛋白酶抑制因子1蛋白

Tissue Inhibitors of Metalloproteinases 1 | CLGI | Collagenase inhibitor | collagenase inhibitor) | EPA | TIMP-1 | EPO | erythroid potentiating activity | Erythroid-potentiating activity | Fibroblast collagenase inhibitor | FLJ90373 | HCI | metalloprotein

rp154745-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Function Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling.

Measured by its ability to inhibit human MMP-2 cleavage of a fluorogenic peptide substrate Mca-PLGL-Dpa-AR-NH2. The IC50 value is <3.5 nM, as measured under the described conditions.

重组表达

21.1 kDa

C-His

32 kDa under reducing conditions.

HEK293 Accession #: P12032 | HEK293

<0.1 EU/μg

小鼠(Mouse)

25-205 aa

CSCAPPHPQTAFCNSDLVIRAKFMGSPEINETTLYQRYKIKMTKMLKGFKAVGNAADIRYAYTPVMESLCGYAHKSQNRSEEFLITGRLRNGNLHISACSFLVPWRTLSPAQQRAFSKTYSAGCGVCTVFPCLSIPCKLESDTHCLWTDQVLVGSEDYQSRHFACLPRNPGLCTWRSLGARHHHHHH

Yes

Yes