Recombinant Human PDGF AA Protein

PDGF1 | PDGF-A | PDGFAA | PDGF-AA

rp156179-10μg

10μg

无载体

≥95%(SDS-PAGE)

Platelet-derived growth factor alpha (PDGFA) is frequently upregulated in various cancers and thought to function as a key player in the development and progression of tumor growth by regulating aspects of cell proliferation, angiogenesis and metastasis. The human platelet-derived growth factor A chain gene (PDGFA) on chromosome 7p22 encodes an important mitogen. Within PDGFA lies a complex minisatellite structure that results in partial duplications of exon 4 and the IVS4 splice donor site.

Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 2.1 ng/mL.

重组表达

14.3 kDa

No tag

17.3 kDa, under reducing conditions; 31.3 kDa, under non-reducing conditions.

E. coli Accession #: P04085 | E. coli

<1.0 EU/μg

人(Human)

87-211 aa

SIEEAVPAVCKTRTVIYEIPRSQVDPTSANFLIWPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHLECACATTSLNPDYREEDTGRPRESGKKRKRKRLKPT​

No

Yes