Recombinant Human NRG1-beta 1 Protein

重组人NRG1-beta 1蛋白 | 重组人类 NRG1-beta 1 蛋白

SMDF | Sensory and motor neuron-derived factor | ProNRG1 | Pro-NRG1 | pro-neuregulin-1, membrane-bound isoform | OTTHUMP00000230605 | OTTHUMP00000230603 | OTTHUMP00000225545 | OTTHUMP00000225477 | OTTHUMP00000225422 | OTTHUMP00000225421 | OTTHUMP000002254

rp156330-10μg

10μg

无载体

≥95%(SDS-PAGE)

Protein Function: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity).

Measured in a cell proliferation assay using MCF‑7 human breast cancer cells. The ED50 for this effect is typically 0.73 ng/mL.

重组表达

8.2 kDa

No tag

11.1 kDa, under reducing conditions; 11.2 kDa, under non-reducing conditions

E. coli Accession #: Q02297-11 | E. coli

<1.0 EU/μg

人(Human)

121-191 aa

TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQK

No

Yes