Recombinant Human IGF-I/IGF-1 Protein

重组人IGF-I/IGF-1蛋白 | 重组人胰岛素样生长因子1蛋白

IBP1 | IGF1 | IGF-1 | IGF1A | IGFI | IGF-I | IGF-IA | IGF-IB | insulin-like growth factor 1 (somatomedin C) | insulin-like growth factor 1 | insulin-like growth factor I | insulin-like growth factor IA | insulin-like growth factor IB | Mechano growth fact

rp156332-10μg

10μg

无载体

≥90%(SDS-PAGE)

Insulin-like growth factor 1 (IGF-1 or IGF-I), also known as somatomedin C, is the dominant effector of growth hormone and is structurally homologous to proinsulin. Human IGF-1 is synthesized as two precursor isoforms with N- and alternate Cterminal propeptides. These isoforms are differentially expressed by various tissues. The 7.6 kDa mature IGF1 is identical between isoforms and is generated by proteolytic removal of the N- and Cterminal regions. Mature human IGF-1 shares 94% and 96% aa sequence identity with mouse and rat IGF-1, respectively, and exhibits cross-species activity. It shares 64% aa sequence identity with mature human IGF2. Circulating IGF-1 is produced by hepatocytes, while local IGF-1 is produced by many other tissues in which it has paracrine effects. IGF-1 induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally. IGF-1 regulates glucose and fatty acid metabolism, steroid hormone activity, and cartilage and bone metabolism. It plays an important role in muscle regeneration and tumor progression. IGF-1 binds IGF1R, IGF2R, and the insulin receptor, although its effects are mediated primarily by IGF1R. IGF-1 association with IGF binding proteins increases its plasma halflife and modulates its interactions with receptors.

Measured in a cell proliferation assay using MCF-7 cells. The ED50 for this effect is typically 28.6 ng/mL.

重组表达

7.7 kDa

No tag

10.2 & 13.8 kDa, under reducing conditions; 10.4 & 13.8 & 20.9 kDa, under non-reducing conditions.

E. coli Accession #: P05019 | E. coli

<1.0 EU/μg

人(Human)

49-118 aa

GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA

No

Yes