Recombinant Human LR3 IGF-I/IGF-1 GMP Protein

胰岛素样生长因子I重组蛋白 | 重组人 LR3 IGF-I/IGF-1 GMP 蛋白

IBP1 | IGF1 | IGF-1 | IGF1A | IGFI | IGF-I | IGF-IA | IGF-IB | insulin-like growth factor 1 (somatomedin C) | insulin-like growth factor 1 | insulin-like growth factor I | insulin-like growth factor IA | insulin-like growth factor IB | IGF | somatomedin-C

rp163958-GMP-200μg

200μg

无动物源

≥95%(SDS-PAGE&SEC-HPLC)

从血浆中分离出来的胰岛素样生长因子在结构上和功能上与胰岛素有关，但具有更高的生长促进活性。可能是成骨细胞中[1-14C]-2-脱氧-D-葡萄糖（2DG）转运和糖原合成的生理调节剂。可刺激大鼠骨源性成骨细胞（PyMS）中的葡萄糖转运，其浓度远低于胰岛素，不仅在糖原和 DNA 合成方面有效，而且在提高葡萄糖摄取方面也有效。

Measured in a serum-free cell proliferation assay using MCF7 human breast cancer cells. The ED50 for this effect is 0.3-1.5 ng/mL. IGFBP-3 does not inhibit its activity.

重组表达

9 kDa

No tag

8 kDa, under reducing conditions

E. coli Accession #: P05019.1 | E. coli

<0.01 EU/μg

人(Human)

49-118 aa (E51R)

MFPAMPLSSLFVNGPRTLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA

Yes

Yes

Met-Phe-Pro-Ala-Met-Pro-Leu-Ser-Ser-Leu