Recombinant Mouse Activin RIIA Protein

激活素A受体ⅡA(ACVR2A)重组蛋白

activin A receptor, type II | activin A receptor, type IIA | Activin receptor type IIA | activin receptor type-2A | Activin RIIA | ActivinRIIA | ACTRII | ACTRIIA | ACVR2A | ACTR-IIA | AVR2A | EC 2.7.11 | EC 2.7.11.30 | Acvr2 | TactrII

rp164335-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6.

Measured by its ability to inhibit Activin A-induced hemoglobin expression in K562 human chronic myelogenous leukemia cells. The ED50 for this effect is 6-36 ng/mL in the presence of 3 ng/mL of recombinant human Activin A.

重组表达

16 kDa

C-His

25 - 35 kDa, under reducing conditions; 25 - 35 kDa, under non-reducing conditions.

HEK293 Accession #: P27038 | HEK293

<0.1 EU/μg

小鼠(Mouse)

1-134 aa

Yes

Yes

MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWERDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCIEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPHHHHHH