Recombinant Chicken Caronte Protein

鸡胡萝卜素重组蛋白 | 鸡胡萝卜素重组蛋白

Caronte | Chicken Caronte | CER1 | CAR | cerberus 1, DAN family BMP antagonist | Caronte | Chicken Caronte | CER1 | CAR | cerberus 1, DAN family BMP antagonist

rp165562-10μg

10μg

无动物源

≥90%(SDS-PAGE)

Cerberus/DAN家族分泌糖蛋白。Caronte 在左侧副中胚层中表达，是鸡胚胎发育过程中负责将左侧位置信息从节点传递到侧板中胚层（LPM）外围的分子。Caronte 的功能是 BMP 拮抗剂，通过干扰双侧产生的 BMP 的抑制活性，诱导 LPM 中的 Nodal 和下游基因。此外，Caronte 对 BMPs 的拮抗作用还能诱导中线左侧基因的表达。在胚胎头部和躯干双侧不对称的形成过程中，作为 Nodal/BMP 通路活性调节剂的细胞因子。

Measured by its ability to cause heart reversals when injected into the right lateral plate of a population of Xenopus neurulae embryos. 80 ng per embryo induces 25-50% heart reversals. Measured by its binding ability in a functional ELISA. Immobilized rchCaronte/Fc Chimera at 5 µg/mL (100 µL/well) can bind hBMP-4 with a linear range of 0.8-100 ng/mL.

重组表达

22.6 kDa

C-His

36 kDa, under reducing conditions

HEK293 Accession #: Q9PUK2 | HEK293

<0.1 EU/μg

鸡(Chicken)

16-272 aa & 18-272 aa

DTEPQPDSQQRKRRPLQHLFYLDRNLLESQSFHELVGENPVGVKETQEEPSFFIAFPQTAGESQKQGEKKMSRFILPNAELYAHQDLRTWAAPKEISPVENFSPSYYSNKRDVEPPYRKDAKKFWDHFMLRKNSASEEVVLPIKTNEMHQETCRTLPFSQSVAHESCEKVIVQNNLCFGKCSSFHVPGPDDRLYTFCSKCLPTKFSMKHFDLNCTSSVPVVKKVMIVEECNCETQKIEDPLLGSLQSDFLGNVPEHNHHHHHH

Yes

Yes