Recombinant Cynomolgus DC-SIGN/CD209 Protein

CD209分子(CD209)重组蛋白

CD209 antigendendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbingnon-integrin | CD209 molecule | CD209 | CDSIGNHIV gpl20-binding protein | CLEC4L | CLEC4LC-type lectin domain family 4 member L | DCSIGN | DC-SIGN | DC-SIGN1 | DC-SIGN1

rp166108-10μg

10μg

无动物源

≥95%(SDS-PAGE)

在 DC 上，它是 ICAM2 和 ICAM3 的高亲和力受体，能与甘露糖样碳水化合物结合。它可能是一种 DC 滚动受体，通过与内皮 ICAM2 结合，介导 DC 原体从血液向组织的跨内皮迁移。在 DC 与 T 细胞之间形成的免疫突触中，似乎通过与 T 细胞上的 ICAM3 结合来调节 DC 诱导的 T 细胞增殖。

Measured by the ability of the immobilized protein to support the adhesion of ICAM-3 expressing CHO Chinese hamster ovary cells. The ED50 for this effect is 1.25-8 μg/mL.

重组表达

40 kDa

C-His

41 - 52 kDa, under reducing conditions; 41 - 52 kDa, under non-reducing conditions.

HEK293 Accession #: XP_015296329.1 | HEK293

<0.1 EU/μg

食蟹猴(Cynomolgus monkey)

62-406 aa

KVPSSLSQGQSKQDAIYQNLTQLKVAVSELSEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYEELTRLKAAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKQQEIYQELSRLKAAVGDLPEKSKQQEIYQKLTQLKAAVDGLPDRSKQQEIYQELIQLKAAVDLEGWTDTGIWTTSSEPSPDRPPPTERLCHPCPWEWTFFQGNCYFMSNSQRNWHDSITACQEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNHEGTWQWVDGSPLLPSFKQYWNKGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASCSGDEERLLSPAPTTPNPPPEHHHHHH

Yes

Yes