Recombinant Mouse TNF RII/TNFRSF1B Protein

重组小鼠TNF RII/TNFRSF1B蛋白 | 重组小鼠肿瘤坏死因子受体超家族成员1B蛋白

CD120b | Etanercept | p75 TNF receptor | p75 | TBPII | TNFR | soluble TNFR1B variant 1 | TNF RII | CD120b antigen | TNFBR | p80 TNF-alpha receptor | TNF-R2 | TNFR2 | TNFR1B | TNF-R75 | TNFR80 | TNFRII | TNF-RII | TNF-R-II | TNFR-II | TNFRSF1B | tumor necr

rp166320-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Function Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

Measured in a cytotoxicity assay using L929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D (A113142). The ED50 for this effect is typically 0.95 ng/mL in the presence of 0.5 ng/mL of Recombinant Mouse TNF-alpha Protein (rp154759).

重组表达

52 kDa

C-hFc & His

60 - 90 kDa, under reducing conditions; 120 - 180 kDa, under non-reducing conditions.

HEK293 Accession #: P25119 | HEK293

<0.1 EU/μg

小鼠(Mouse)

23-258 aa

VPAQVVLTPYKPEPGYECQISQEYYDRKAQMCCAKCPPGQYVKHFCNKTSDTVCADCEASMYTQVWNQFRTCLSCSSSCTTDQVEIRACTKQQNRVCACEAGRYCALKTHSGSCRQCMRLSKCGPGFGVASSRAPNGNVLCKACAPGTFSDTTSSTDVCRPHRICSILAIPGNASTDAVCAPESPTLSAIPRTLYVSQPEPTRSQPLDQEPGPSQTPSILTSLGSTPIIEQSTKGGENLYFQGMDPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH

Yes

Yes