Recombinant Human IL-17A/F Heterodimer Protein

重组人IL-17A/F蛋白

CTLA8cytotoxic T-lymphocyte-associated serine esterase 8 | Cytotoxic T-lymphocyte-associated antigen 8 | Cytotoxic T-Lymphocyte-Associated Protein 8 | IL17 | IL-17 | IL-17A | IL-17A/F Heterodimer | interleukin 17 (cytotoxic T-lymphocyte-associated serine

rp167375-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Relevance: IL-17F stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis. IL-17A induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts.

Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 0.4‑2 ng/mL.

重组表达

31 kDa

C-His (IL17F)

16 - 23 kDa, under reducing conditions; 35 - 42 kDa, under non-reducing conditions.

HEK293 Accession #: Q16552,Q96PD4 | HEK293

<0.1 EU/μg

人(Human)

24-155 aa (IL17A)&31-163 aa (IL17F)

IL17A: GITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA IL17F: RKIPKVGHTFFQKPESCPPVPGGSMKLDIGIINENQRVSMSRNIESRSTSPWNYTVTWDPNRYPSEVVQAQCRNLGCINAQGKEDISMNSVPIQQETLVVRRKHQGCSVSFQLEKVLVTVGCTCVTPVIHHVQHHHHHH

Yes

Yes