Recombinant Human Notum Protein

重组人Notum蛋白 | 重组人背板胶质乙酰酯酶蛋白 | 重组人Notum蛋白 | 重组人背板胶质乙酰酯酶蛋白

EC 3.- | notum pectinacetylesterase homolog (Drosophila) | Notum | protein notum homolog | NOTUM | hNOTUM | EC 3.- | notum pectinacetylesterase homolog (Drosophila) | Notum | protein notum homolog | hNOTUM

rp167487-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Function Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors.

Measured by its ability to inhibit Wnt induced TCF reporter activity in HEK293 human embryonic kidney cells. The ED50 for this effect is 0.1-0.6 μg/mL in the presence of 0.5 μg/mL of Recombinant Human Wnt-3a.

重组表达

43 kDa

C-His

43 kDa, under reducing conditions; 40 kDa, under non-reducing conditions.

HEK293 Accession #: Q6P988 | HEK293

<0.1 EU/μg

人(Human)

81-451 aa (C330S)

SAQQLNEDLRLHLLLNTSVTCNDGSPAGYYLKESRGSRRWLLFLEGGWYCFNRENCDSRYDTMRRLMSSRDWPRTRTGTGILSSQPEENPYWWNANMVFIPYCSSDVWSGASSKSEKNEYAFMGALIIQEVVRELLGRGLSGAKVLLLAGSSAGGTGVLLNVDRVAEQLEKLGYPAIQVRGLADSGWFLDNKQYRHTDCVDTITCAPTEAIRRGIRYWNGVVPERCRRQFQEGEEWNCFFGYKVYPTLRSPVFVVQWLFDEAQLTVDNVHLTGQPVQEGLRLYIQNLGRELRHTLKDVPASFAPACLSHEIIIRSHWTDVQVKGTSLPRALHCWDRSLHDSHKASKTPLKGCPVHLVDSCPWPHCNPSCPTHHHHHH

Yes

Yes