Recombinant Human Noggin GMP Protein

重组人头蛋白 | 重组人 Noggin GMP 蛋白

NOG | Noggin | SYM1 | symphalangism 1 (proximal) | synostoses (multiple) syndrome 1 | SYNS1 | SYNS1A

rp167884-GMP-50μg

50μg

无动物源

≥90%(SDS-PAGE&SEC-HPLC)

骨形态发生蛋白（BMP）信号的抑制剂，神经管和体节的生长和模式化需要这种信号。对软骨形态发生和关节形成至关重要。通过与 GDF5 以及 GDF6 的相互作用抑制软骨细胞分化（PubMed:21976273, PubMed:26643732）。

Measured by its ability to inhibit BMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is 0.1-0.4 μg/mL in the presence of 30 ng/mL of Recombinant Human BMP‑4

重组表达

49.6 kDa (monomer)

C-hFc

58-62 kDa, under reducing conditions. 110-130 kDa, under non-reducing conditions

HEK293 Accession #: Q13253.1 | HEK293

<0.1 EU/μg

人(Human)

28-232 aa

QHYLHIRPAPSDNLPLVDLIEHPDPIFDPKEKDLNETLLRSLLGGHYDPGFMATSPPEDRPGGGGGAAGGAEDLAELDQLLRQRPSGAMPSEIKGLEFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKRSCSVPEGMVCKPSKSVHLTVLRWRCQRRGGQRCGWIPIQYPIISECKCSCIEGRMDPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK

Yes

Yes

Amino acid sequencing was blocked, suggesting it is consistent with Gln28 as the first N-terminal amino acid. Predicted N-terminal sequence: Gln28-His-Tyr-Leu-His-Ile-Arg-Pro-Ala-Pro