Recombinant Human PDGF-BB GMP Protein

血小板衍生生长因子BB(PDGF BB)重组蛋白 | 重组人PDGF-BB GMP蛋白

c-sis | IBGC5 | PDGF2 | PDGF-2 | PDGFB | Platelet-derived growth factor subunit B | SIS | SSV | PDGFBB | PDGF-BB

rp168345-GMP-50μg

50μg

无动物源

≥75%(SDS-PAGE&SEC-HPLC)

生长因子，在胚胎发育、细胞增殖、细胞迁移、存活和趋化等方面起着重要的调节作用。是间充质来源细胞的强效有丝分裂原（PubMed:26599395）。 对中枢神经系统、皮肤、肺、心脏和胎盘中的周细胞和血管平滑肌细胞的正常增殖和募集是必需的。正常的血管发育和肾小球的正常发育需要它。在伤口愈合中发挥重要作用。信号通过与 PDGFA 形成异二聚体来调节（相似）。

Measured in a cell proliferation assay using NR6R‑3T3 mouse fibroblast cells. The ED50 for this effect is 1.5-6 ng/mL. The specific activity of recombinant human PDGF-BB is >7.5 x 10^5 IU/mg, which is calibrated against the human PDGF-BB WHO International Standard (NIBSC code: 94/728).

重组表达

12.3 kDa (monomer)

No tag

13 kDa, under reducing conditions

E. coli Accession #: P01127 | E. coli

<0.01 EU/μg

人(Human)

82-190 aa

SLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVT

Yes

Yes

Ser-Leu-Gly-Ser-Leu-Thr-Ile-Ala-Glu-Pro