Recombinant Human M-CSF GMP Protein

巨噬细胞集落刺激因子1重组蛋白 | 重组人M-CSF GMP蛋白

colony stimulating factor 1 (macrophage) | CSF1 | CSF-1 | Lanimostim | macrophage colony stimulating factor | macrophage colony-stimulating factor 1 | MCSF | M-CSF | MCSFlanimostim | MGC31930 | PG-M-CSF

rp168376-GMP-25μg

25μg

无动物源

≥97%(SDS-PAGE&SEC-HPLC)

细胞因子，在调节造血前体细胞（尤其是巨噬细胞和单核细胞等单核吞噬细胞）的存活、增殖和分化方面发挥着重要作用。促进促炎趋化因子的释放，从而在先天免疫和炎症过程中发挥重要作用。在调节破骨细胞增殖和分化、调节骨吸收方面发挥重要作用，是正常骨骼发育所必需的。男性和女性正常生育所必需。促进肌动蛋白细胞骨架的重组，调节膜皱褶的形成、细胞粘附和细胞迁移。在脂蛋白清除中发挥作用。

Measured in a cell proliferation assay using M‑NFS‑60 mouse myelogenous leukemia lymphoblast cells. The ED50 for this effect is 0.5-1.5 ng/mL.The specific activity of Recombinant Human M-CSF is >6.0 x 10^7 IU/mg, which is calibrated against the human M-CSF WHO International Standard (NIBSC code: 89/512).

重组表达

18.5 kDa (monomer)

No tag

37 kDa, under non-reducing conditions

E. coli Accession #: NP_757350.2 | E. coli

<0.01 EU/μg

人(Human)

33-190 aa

MEEVSEYCSHMIGSGHLQSLQRLIDSQMETSCQITFEFVDQEQLKDPVCYLKKAFLLVQDIMEDTMRFRDNTPNAIAIVQLQELSLRLKSCFTKDYEEHDKACVRTFYETPLQLLEKVKNVFNETKNLLDKDWNIFSKNCNNSFAECSSQGHERQSEGS

Yes

Yes

Met-Glu-Glu-Val-Ser-Glu-Try-(Cys)-Ser-His