Recombinant Human CD30/TNFRSF8 Protein

重组人CD30/TNFRSF8蛋白 | 重组人 CD30/TNFRSF8 蛋白

CD30 | CD30KI-1 | CD30L receptor | cytokine receptor CD30 | D1S166EKi-1 | Ki-1 antigen | Lymphocyte activation antigen CD30 | TNFRSF8 | tumor necrosis factor receptor superfamily member 8 | tumor necrosis factor receptor superfamily, member 8 | CD30 antig

rp169577-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Protein Function:： CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor (TNFR) superfamily. CD30 protein is expressed by activated, but not resting, T and B cells. CD30 can regulate proliferation of lymphocytes and may also play an important role in human immunodeficiency virus replication. As a regulator of apoptosis, CD30 protein induces cell death or proliferation, depending on the cell type, and has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. CD30 protein expression is upregulated in various hematological malignancies, including Reed-Sternberg cells in Hodgkin's disease (HD), anaplastic large cell lymphoma (ALCL) and subsets of Non-Hodgkin's lymphomas (NHLs), and CD30 is also linked to leukocytes in patients with chronic inflammatory diseases, including lupus erythematosus, asthma, rheumatoid arthritis and atopic dermatitis (AD).

Immobilized Recombinant Human CD30 Protein (rp169577) at 1.0 μg/mL can bind Brentuximab (anti-TNFRSF8) (Ab170548) with the EC50 of 119.9 ng/mL.

重组表达

39.2 kDa

C-His

55.0-99.0 kDa, under reducing conditions

HEK293 Accession #: P28908 | HEK293

<1.0 EU/μg

人(Human)

1-379 aa

MRVLLAALGLLFLGALRAFPQDRPFEDTCHGNPSHYYDKAVRRCCYRCPMGLFPTQQCPQRPTDCRKQCEPDYYLDEADRCTACVTCSRDDLVEKTPCAWNSSRVCECRPGMFCSTSAVNSCARCFFHSVCPAGMIVKFPGTAQKNTVCEPASPGVSPACASPENCKEPSSGTIPQAKPTPVSPATSSASTMPVRGGTRLAQEAASKLTRAPDSPSSVGRPSSDPGLSPTQPCPEGSGDCRKQCEPDYYLDEAGRCTACVSCSRDDLVEKTPCAWNSSRTCECRPGMICATSATNSCARCVPYPICAAETVTKPQDMAEKDTTFEAPPLGTQPDCNPTPENGEAPASTSPTQSLLVDSQASKTLPIPTSAPVALSSTGK​HHHHHH

Yes

Yes