Recombinant Human CD47 Protein

重组人CD47蛋白

antigen identified by monoclonal 1D8 | Antigenic surface determinant protein OA3 | CD47 antigen (Rh-related antigen, integrin-associated signal transducer) | CD47 antigen | CD47 glycoprotein | CD47 molecule | CD47 | IAP | IAPintegrin associated protein |

rp169585-10μg

10μg

无动物源

≥95%(SDS-PAGE)

CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain. CD47 may play a role in membrane transport and/or integrin dependent signal transduction. It may prevent premature elimination of red blood cells. It also may be involved in membrane permeability changes induced following virus infection. By acting as an adhesion receptor for THBS1 on platelets, CD47 plays a role in both cell adhesion and in the modulation of integrins. It also plays an important role in memory formation and synaptic plasticity in the hippocampus.

Immobilized Recombinant Human SIRP alpha/CD172a protein (rp183642) at 2.0 μg/mL can bind Recombinant Human CD47 protein (rp169585) with the EC50 of 308.6 ng/mL. Immobilized Recombinant Human CD47 protein (rp169585) at 1.0 μg/mL can bind Ligufalimab (anti-CD47) (Ab191922) with the EC50 of 62.0 ng/mL.

重组表达

14.5 kDa

No tag

32.1-40.9 kDa, under reducing conditions; 46.4-63.5 kDa, under non-reducing conditions.

CHO Accession #: Q08722 | CHO

<1.0 EU/μg

人(Human)

1-139 aa

GPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK​

Yes

Yes