Recombinant Human CNTFR alpha Protein

重组人CNTFR alpha蛋白 | 重组人睫状神经营养因子受体α亚基蛋白

Ciliary neurotrophic factor receptor | Ciliary neurotrophic factor receptor alpha | Ciliary neurotrophic factor receptor subunit alpha | CNTF Receptor alpha | CNTF receptor subunit alpha | CNTFR | CNTFR Alpha | CNTFR-alpha | CNTFR_HUMAN

rp169598-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Ciliary neurotrophic factor (CNTF) is a member of the cytokine family. It is a polypeptide hormone that have functions in promoting neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. Its actions appear to be restricted to the nervous system. Ciliary neurotrophic factor (CNTF) has biological effects through the activation of a multi-subunit receptor complex, consisting of an extracellular CNTF binding subunit(CNTFα) and two transmembrane signal transduction proteins: glycoprotein gp130 and LIF receptor. CNTF is considered as a potent survival factor of neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. CNTF is also a survival factor for neurons of the peripheral sensory sympathetic, and ciliary ganglia. It has been reported that CNTF could be an agent that has therapeutic potential and possibly induces differentiation of large multipolar ganglionic phenotype in a subset of progenitors.

Measured in a cell proliferation assay using TF-1 cells. The ED50 for this effect is typically 21.1 ng/mL in the presence of 1.0 μg/mL Recombinant Human CNTFR alpha Protein (rp169598). The proliferative effect can be enhanced up to 100-fold by the addition of Recombinant Human CNTF R alpha.

重组表达

36.9 kDa

C-His

42.6-72.7 kDa, under reducing conditions; 43.5-63.0 kDa, under non-reducing conditions.

HEK293 Accession #: P26992 | HEK293

<1.0 EU/μg

人(Human)

23-346 aa

MAAPVPWACCAVLAAAAAVVYAQRHSPQEAPHVQYERLGSDVTLPCGTANWDAAVTWRVNGTDLAPDLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMVCEKDPALKNRCHIRYMHLFSTIKYKVSISVSNALGHNATAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHATPWTEEPRHLTTEAQAAETTTSTTSSLAPPPTTKICDPGELGSGGGPSAPFLVSVPITLALAAAAATASSLLIHHHHHH​

Yes

Yes