Recombinant Human Fc gamma RIIIA/CD16a Protein

重组人Fc gamma RIIIA/CD16a蛋白 | 重组人 FcγRIIIA/CD16a 蛋白

CD16a | CD16FCRIIIA | Fc fragment of IgG, low affinity IIIa, receptor (CD16a) | Fc fragment of IgG, low affinity IIIa, receptor for (CD16) | Fc gamma receptor III-A | Fc gamma RIIIA | FCG3 | Fc-gamma receptor III-2 (CD 16) | Fc-gamma receptor IIIb (CD16)

rp169611-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Protein Function:： The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also known as CD16a, encodes a transmembrane protein expressed on activated monocytes/macrophages, natural killer (NK) cells, and a subset of T cells. CD16a / FCGR3A is a receptor expressed on NK cells that facilitates antibody dependent cellular cytotoxicity (ADCC) by binding to the Fc portion of various antibodies. CD16a / FCGR3A also has a broader function. CD16a / FCGR3A is directly involved in the lysis of some virus-infected cells and tumor cells by NK cells, independent of antibody binding. Cross-linking of CD16a / FCGR3A on NK cells resulted in increased intracellular Ca2+ levels and a cascade of biochemical events similar to those activated by the T cell receptor. CD16a / FCGR3A on human NK cells is a lysis receptor that mediates the direct killing of some virus infected and tumor cells, independent of antibody ligation.

Testing in progress

重组表达

22.7 kDa

C-His

35.0-55.0 kDa, under reducing conditions; 35.0-55.0 kDa, under non-reducing conditions

HEK293 Accession #: P08637 | HEK293

<1.0 EU/μg

人(Human)

1-208 aa

MWQLLLPTALLLLVSAGMRTEDLPKAVVFLEPQWYRVLEKDSVTLKCQGAYSPEDNSTQWFHNESLISSQASSYFIDAATVDDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVFKEEDPIHLRCHSWKNTALHKVTYLQNGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLFGSKNVSSETVNITITQGLAVSTISSFFPPGYQHHHHHH

Yes

Yes