Recombinant Human MMP-3 Protein

重组人MMP-3蛋白 | 重组人基质金属蛋白酶-3蛋白

CHDS6 | EC 3.4.24 | EC 3.4.24.17 | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | matrix metalloproteinase 3 (stromelysin 1, progelatinase) | Matrix metalloproteinase-3 | MGC126102 | MGC126103 | MMP3 | MMP-3 | proteoglycanase | SL-1 | STMY | S

rp169644-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Matrix metalloproteinases are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP-3 (stromelysin-1), can degrade a broad range of substrates including collagen alpha chains, aggrecan, laminin, fibronectin, elastin, casein, alpha -1 antitrypsin, myelin basic protein, IL-1 beta, IGFBP-3, pro MMP-1, pro MMP-7, pro MMP-8, pro MMP-9 and pro MMP-13. MMP-3 does not cleave the triple helical region of interstitial collagens, a characteristic which distinguishes the stromelysins from the collagenases. The MMP-3 substrate repertoire extends beyond extracellular matrix proteins and implicates MMP-3 in roles other than direct tissue remodelling, for instance, enzyme cascades and cytokine regulation. MMP-3 is expressed by fibroblasts, chrondrocytes, osteoblasts, endothelial cells, smooth muscle cells and macrophages. Structurally, MMP-3 may be divided into several distinct domains; a pro-domain which is cleaved upon activation; a catalytic domain containing the zinc binding site; a short hinge region and a carboxyl terminal (hemopexin-like) domain. Post-translational: Directly cleaved by HTRA2 to produce active form.

Immobilized Recombinant Human MMP-3 Protein (rp169644) at 1.0 μg/mL can bind MMP3 Mouse mAb (Ab176193) with the EC50 of 76.2 ng/mL.

重组表达

53.0 kDa

C-His

53.4-59.7 kDa, under reducing conditions; 50.4-56.2 & 110.8 kDa, under non-reducing conditions.

HEK293 Accession #: P08254 | HEK293

<1.0 EU/μg

人(Human)

1-477 aa

MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNCHHHHHH

Yes

Yes