Recombinant Human IL-32 alpha Protein

重组人IL-32 alpha蛋白 | 重组人白细胞介素32α蛋白

IL32 alpha | IL-32 alpha | IL32 | IL-32alpha | IL-32beta | IL-32delta | IL-32gamma | interleukin 32 | NK4 | TAIF | TAIFa | TAIFb | TAIFc | TAIFd

rp169683-10μg

10μg

无载体

≥95%(SDS-PAGE)

IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathways. It is regulated robustly by other major proinflammatory cytokines and is crucial to inflammation and immune responses. Four of the IL-32 isoforms (alpha, beta, gamma, and delta) are the most representative IL-32 transcripts, and the gamma isoform of IL-32 is the most active, although all isoforms are biologically active. IL-32, a cytokine produced mainly by T, natural killer, and epithelial cells induces significant amounts of TNF alpha and MIP-2 and increases the production of both cytokines in a dose-dependent manner. IL-32 has been implicated in inflammatory disorders, Mycobacterium tuberculosis infections, inflammatory bowel disease, and influenza A virus infection, as well as in some autoimmune diseases, such as rheumatoid arthritis, ulcerative colitis, and in the human stomach cancer, human lung cancer, and breast cancer tissues. Thus, IL-32 expression might be valuable as a biomarker for cancer.

Testing in progress

重组表达

15.7 kDa

N-His

20.1 kDa, under reducing conditions; 20.1 kDa, under non-reducing conditions

E. coli Accession #: P24001 | E. coli

<1.0 EU/μg

人(Human)

2-131 aa

MHHHHHHCFPKVLSDDMKKLKARMHQAIERFYDKMQNAESGRGQVMSSLAELEDDFKEGYLETVAAYYEEQHPELTPLLEKERDGLRCRGNRSPVPDVEDPATEEPGESFCDKSYGAPRGDKEELTPQKCSEPQSSK​

No

Yes