Recombinant Human EpCAM/TROP1 Protein

重组人EpCAM/TROP1蛋白 | 重组人类 EpCAM/TROP1 蛋白

323/A3 | ACSTD1 | antigen identified by monoclonal AUA1 | CD326 antigen | CD326 | Cell surface glycoprotein Trop-1 | chromosome 4, surface marker (35kD glycoprotein) | DIAR5 | 17-1A | EGP | EGP-2 | EGP314 | EGP40 | EpCAM | epithelial cell adhesion molecul

rp170132-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type I transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.

Measured by the ability of the immobilized protein to support the adhesion of NIH-3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 1.068 μg/mL.

重组表达

28.2 kDa

C-His

32.0-42.0 kDa, under reducing conditions

HEK293 Accession #: P16422 | HEK293

<1.0 EU/μg

人(Human)

1-265 aa

MAPPQVLAFGLLLAAATATFAAAQEECVCENYKLAVNCFVNNNRQCQCTSVGAQNTVICSKLAAKCLVMKAEMNGSKLGRRAKPEGALQNNDGLYDPDCDESGLFKAKQCNGTSMCWCVNTAGVRRTDKDTEITCSERVRTYWIIIELKHKAREKPYDSKSLRTALQKEITTRYQLDPKFITSILYENNVITIDLVQNSSQKTQNDVDIADVAYYFEKDVKGESLFHSKKMDLTVNGEQLDLDPGQTLIYYVDEKAPEFSMQGLKHHHHHH

Yes

Yes