Recombinant Human UbcH5a/UBE2D1 Protein

重组人 UbcH5a/UBE2D1蛋白 | 重组人 UbcH5a/UBE2D1 蛋白

E2 ubiquitin-conjugating enzyme D1 | Stimulator of Fe transport (SFT) | UBC4/5 homolog | UbcH5 | (E3-independent) E2 ubiquitin-conjugating enzyme D1 (EC:2.3.2.24) | EC:2.3.2.24 | Ubiquitin-conjugating enzyme E2 D1 | (E3-independent) E2 ubiquitin-conjugati

rp170402-50μg

50μg

无载体

≥90%(SDS-PAGE)

Purity:>90%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： Ubiquitin-conjugating Enzyme H5a (UbcH5a), also known as Ubiquitin-conjugating Enzyme E2D 1 (UBE2D1), is a ubiquitously expressed protein that is related to Stimulator of Iron Transport (SFT). Human UbcH5a/UBE2D1 has a predicted molecular weight of 17 kDa and shares 89% and 88% amino acid (aa) sequence identity with the related family members UbcH5b and UbcH5c, respectively. Human UbcH5a/UBE2D1 shares 100% aa sequence identity with the mouse and rat orthologs. UbcH5a/UBE2D1 has a conserved E2 catalytic core domain that contains an active site cysteine residue, and it interacts with a variety of HECT and RING finger Ubiquitin ligases (E3) to mediate the ubiquitination of specific target proteins. UbcH5a/UBE2D1 interacts with the E3, E6-AP, to conjugate Ubiquitin to the tumor suppressor, p53. Additional protein targets of UbcH5a/UBE2D1 include c-Fos, RIP1, and HIF-1. Pathologically, UbcH5a/UBE2D1 is implicated in protein degradation during cancer and immune responses.

Testing in progress

重组表达

17.4 kDa

N-His

15.3 kDa, under reducing conditions; 15.3 kDa, under non-reducing conditions

E. coli Accession #: P51668 | E. coli

<1.0 EU/μg

人(Human)

1-147 aa

MHHHHHHALKRIQKELSDLQRDPPAHCSAGPVGDDLFHWQATIMGPPDSAYQGGVFFLTVHFPTDYPFKPPKIAFTTKIYHPNINSNGSICLDILRSQWSPALTVSKVLLSICSLLCDPNPDDPLVPDIAQIYKSDKEKYNRHAREWTQKYAM

No

Yes