Recombinant Human IL-1ra/IL-1F3 Protein

重组人IL-1ra/IL-1F3蛋白 | 重组人 IL-1ra/IL-1F3 蛋白

DIRA | ICIL-1ra | IL1F3 | IL-1F3 | IL1ra | IL-1ra | IL-1ra3 | IL1RN | IL-1RN | interleukin 1 receptor antagonist | IRAP | MVCD4

rp170405-50μg

50μg

无载体

≥95%(SDS-PAGE)

>95% (SDS-PAGE)

Purity: >95%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description: IL-1ra was originally isolated from the urine of patients with monocytic leukemia and has also been purified from adherent monocytes. The naturally occurring, fully glycosylated form has an apparent molecular weight of about 25,000 Daltons. The protein shows 26% amino acid homology to IL-1 beta and 19% homology to IL-1 alpha. It will compete with either factor for receptor binding, but does not interact with either one. Human IL-1ra will bind to both types of IL-1 receptor (I and II) on human cells, but reportedly will not block binding to the type II receptor on murine pre-B cell lines. The recombinant, non-glycosylated form of IL-1ra blocks binding of IL-1 to its receptor equally as well as the naturally-occurring, glycosylated form. The IL-1ra has been shown to block the inflammatory responses induced by IL-1 both in vitro and in vivo. Currently, pre-clinical and clinical studies are underway to test possible therapeutic applications for IL-1ra in the treatment of sepsis, rheumatoid arthritis and chronic myelogenous leukemia.

Testing in progress

重组表达

17.1 kDa

No tag

15.9 kDa, under reducing conditions; 15.9 kDa, under non-reducing conditions

E. coli Accession #: P18510 | E. coli

<1.0 EU/μg

人(Human)

26-177 aa

RPSGRKSSKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE

No

Yes