Recombinant Human CXCL4/PF4 Protein

重组人CXCL4/PF4蛋白 | 重组人血小板因子4蛋白

chemokine (C-X-C motif) ligand 4 | C-X-C motif chemokine 4 | CXCL4 | CXCL4iroplact | Iroplact | MGC138298 | Oncostatin-A | PF4 | PF-4 | platelet factor 4 | SCYB4 | Chemokine (C X C motif) ligand 4 | Chemokine (CXC motif) ligand 4 | chemokine ligand 4 | CX

rp170411-10μg

10μg

无载体

≥95%(SDS-PAGE)

Platelet factor 4 (PF4), also known as chemokine (C-X-C motif) ligand 4 (CXCL4), is a small cytokine belonging to the CXC chemokine family. CXCL4/PF4 is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, CXCL4/PF4 probably has a role in inflammation and wound repair. This protein is released during platelet aggregation. CXCL4/PF4 neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. CXCL4 is chemotactic for neutrophils and monocytes. It inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. CXCL4/PF4 is up-regulated in human liver fibrosis and that it plays a nonredundant, functional role in experimental liver fibrosis by mediating stellate cell proliferation, migration, and intrahepatic immune cell recruitment.

Immobilized Recombinant Human CXCL4/PF4 Protein (rp170411) at 2.0 μg/mL can bind U.Penn. patent anti-PF4 (anti-CXCL4) (Ab209769) with the EC50 of 74.0 ng/mL.

重组表达

8.7 kDa

N-His

11.1 kDa, reducing conditions; 11.1 kDa, non-reducing conditions

E. coli Accession #: P02776 | E. coli

<1.0 EU/μg

人(Human)

32-101 aa

MHHHHHHEAEEDGDLQCLCVKTTSQVRPRHITSLEVIKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLLES

No

Yes