Recombinant Human CXCL10/IP-10 Protein

重组人CXCL10/IP-10蛋白 | 重组人 CXCL10/IP-10 蛋白

chemokine (C-X-C motif) ligand 10 | CRG2 | CRG-2 | CXCL10 | gIP-10 | IFI10 | INP10 | IP-10 | mob-1 | SCYB10 | C7

rp170434-10μg

10μg

无载体

≥90%(SDS-PAGE)

Protein Function: (C-X-C motif) ligand (CXCL)10 (CXCL10) belongs to the ELR(-) CXC subfamily chemokine. CXCL10/IP-10 exerts its function through binding to chemokine (C-X-C motif) receptor 3 (CXCR3), a seven trans-membrane receptor coupled to G proteins. CXCL10/IP-10 and its receptor, CXCR3, appear to contribute to the pathogenesis of many autoimmune diseases, organ specific (such as type 1 diabetes, autoimmune thyroiditis, Graves' disease and ophthalmopathy), or systemic (such as rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, mixed cryoglobulinemia, Sjögren syndrome, or systemic sclerosis). CXCL10/IP-10 is secreted by several cell types including endothelial cells, fibroblasts, keratinocytes, thyrocytes, preadipocytes, etc. Determination of high level of CXCL10/IP-10 in peripheral fluids is therefore a marker of host immune response.

Immobilized Recombinant Human CXCL10/IP-10 Protein (rp170434) at 1.0 μg/mL can bind Eldelumab (anti-CXCL10) (Ab170882) with the EC50 of 268.7 ng/mL.

重组表达

20.8 kDa

No tag

11.3 kDa, under reducing conditions

E. coli Accession #: P02778 | E. coli

<1.0 EU/μg

人(Human)

22-98 aa

VPLSRTVRCTCISISNQPVNPRSLEKLEIIPASQFCPRVEIIATMKKKGEKRCLNPESKAIKNLLKAVSKERSKRSP

No

Yes