Recombinant Human CD64 Protein

重组人CD64蛋白 | 重组人高亲和力免疫球蛋白 γ Fc 受体 I蛋白

CD64, CD64a, FCGR1, FcgRI, FcgRIA, FCRI, FcRIA

rp175903-10μg

10μg

无动物源

≥90%(SDS-PAGE)

High affinity immunoglobulin gamma Fc receptor I, also known as FCGR1 and CD64, is an integral membraneglycoprotein and a member of the immunoglobulin superfamily. CD64 is a high affinity receptor for the Fc region of IgG gamma and functions in both innate and adaptive immune responses. Receptors that recognize the Fc portion of IgG function in the regulation of immune response and are divided into three classes designated CD64, CD32, and CD16. CD64 is structurally composed of asignal peptidethat allows its transport to the surface of a cell, threeextracellularimmunoglobulin domainsof the C2-type that it uses to bind antibody, a hydrophobictransmembrane domain, and a short cytoplasmic tail. CD64 isconstitutivelyfound on only macrophages and monocytes, but treatment of polymorphonuclear leukocyteswith cytokines likeIFNγandG-CSFcan induce CD64 expression on these cells. The inactivation of the mouse CD64 resulted in a wide range of defects in antibody Fc-dependent functions. Mouse CD64 is an early participant in Fc-dependent cell activation and in the development of immune responses. Post-translational: Phosphorylated on serine residues.

Immobilized Recombinant Human CD64 protein (rp175903) at 2.0 μg/mL can bind CD64 Mouse mAb (Ab007054) with the EC50 of 976.9 ng/mL.​

重组表达

31.4 kDa

C-His

41.9-56.9 kDa, under reducing conditions; 40.3-56.4 kDa, under non-reducing conditions.

HEK293 Accession #: P12314 | HEK293

<1.0 EU/μg

人(Human)

16-288 aa

MWLIIALILGAPVAEQQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNGTATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAGISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRNTSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPHHHHHH

Yes

Yes