Recombinant Canine CD14 Protein

重组狗CD14蛋白 | 重组犬CD14蛋白

CD14 | CD14 molecule | Monocyte differentiation antigen CD14 | Myeloid cell-specific leucine-rich glycoprotein

rp175909-50μg

50μg

无动物源

≥95%(SDS-PAGE)

>95% (SDS-PAGE)

Purity:>95%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL-) and mediates the cytokine release induced by LDL-.

重组表达

38.8 kDa

C-His

49.6-56.9 kDa, under reducing conditions; 47.4-54.2 kDa, under non-reducing conditions

HEK293 Accession #: A0A1S7J0A8 | HEK293

<1.0 EU/μg

狗(Canine)

1-373 aa

MMRTPCLLLLLLPPVLCVSETSLEPCEVDDDDFRCFCNFTDPQPDWSSAFQCMIAVEVEIHGGGRSLEQFLKGADADPKQYADMVRALRLRRLTVASAQVPAVLVTAFLRALGYSRLKELTLQDLEVTGTPPPPPLEATGPALSTLTLRNVSWATGSAWLAELQRWLKPGLKVLNIAQAHSLAFSCARLRTFPALTTLDLSDNPGLGEHGLASALCPQKFPALQALVLRNAGMHTPNGVCAAMAVAGVQPRHLDLSHNSLRATAPGAPACVWPSALDSLNLSFSGLGQVPKGLPARLSVLDLRCNKLNREPRLEELPKVSNLTLDGNPFLDPEAPKYQENPTTSGVVPSCARSGLAVGMSGTLAVLQRVGGFAHHHHHH

Yes

Yes