Recombinant Canine CD16 Protein

重组狗CD16蛋白 | 重组犬CD16蛋白

Low affinity immunoglobulin gamma Fc region receptor III-A | IgG Fc receptor III-A | FcgammaRIIIA | CD16a

rp176255-50μg

50μg

无动物源

≥95%(SDS-PAGE)

>95% (SDS-PAGE)

Purity:>95%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG) (By similarity). Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC). Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger. Mediates IgG effector functions on natural killer (NK) cells. Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation (By similarity). Fc-binding subunit that associates with FCER1G adapters to form functional signaling complexes. Following the engagement of antigen-IgG complexes, triggers phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapters with subsequent activation of phosphatidylinositol 3-kinase signaling and sustained elevation of intracellular calcium that ultimately drive NK cell activation (By similarity). Mediates enhanced ADCC in response to afucosylated IgGs.

重组表达

22.0 kDa

C-His

37.0-54.0 kDa, under reducing conditions; 37.0-54.0 kDa, under non-reducing conditions

HEK293 Accession #: E2RP87 | HEK293

<1.0 EU/μg

狗(Canine)

1-206 aa

MWQLVSSTALLLLVSAGTQAADVPKAVVVLEPKWNRVLTMDSVTLKCQGDHLLRDNYTWLHNGRPISNQISTYIIKNASIKNSGEYRCQTDQSKLSDPVQLEVHTGWLLLQVPRLVFQEGELIQLKCHSWKNTPVRNVQYFQNGRGKKFFYNNSEYHIPAATSEHNGSYFCRGIIGKKNESSEAVNIIIQGSSLPSTSLLLSHWPQHHHHHH

Yes

Yes